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Cayman BIO-Acetoxime
List Price
$268.00
Your Price
$268.00
Cayman BIO-Acetoxime - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16329-10
MFG.PART:
16329-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO (Item No. 13123).1,2 It potently inhibits GSK3α/β (IC50 = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC50s = 2.4, 4.3, and 63 µM, respectively).1,2 BIO-Acetoxime has been used to study the role of GSK3 in the Wnt/β-catenin pathway.3 It also suppresses the cytopathic effects of herpes viruses and reduces viral yields in human oral epithelial cells.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-indol-2-one
CAS Number
740841-15-0
Synonyms
- 6-Bromoindirubin-3-acetoxime
- GSK3 Inhibitor X
Molecular Formula
C18H12BrN3O3
Formula Weight
398.2
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
λmax
216, 248, 290, 325, 523 nm
SMILES
CC(O/N=C(/C(N1)=C2C(NC3=C\2C=CC(Br)=C3)=O)C4=C1C=CC=C4)=O
InChi Code
InChI=1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15+,22-16+
InChi Key
MENDIXKFTXYTHJ-TWNGPSNKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16329-10 |
|---|---|
| Supplier Part Number | 16329-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 740841-15-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |