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Cayman Pregnenolone Carbonitrile
List Price
$255.00
Your Price
$255.00
Cayman Pregnenolone Carbonitrile - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16343-250
MFG.PART:
16343-250
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations.1,2,3 It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7α-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion.2,3,4 Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3β-hydroxy-20-
CAS Number
1434-54-4
Synonyms
- PCN
- Pregnenolone 16α-carbonitrile
- SC-4674
Molecular Formula
C22H31NO2
Formula Weight
341.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- Acetonitrile: 1 mg/mL
- Ethanol: 1 mg/mL
- Methanol: 1 mg/mL
SMILES
O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])C[C@@H](C#N)[C@@H]4C(C)=O
InChi Code
InChI=1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
InChi Key
VSBHRRMYCDQLJF-ZDNYCOCVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16343-250 |
|---|---|
| Supplier Part Number | 16343-250 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1434-54-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |