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Cayman Dna Base Excision Repair Pathway Inhibitor; Purity- Greate
List Price
$130.00
Your Price
$130.00
Cayman Dna Base Excision Repair Pathway Inhibitor; Purity- Greater Than Or Equal To 98%; Size- 100 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16348-100
MFG.PART:
16348-100
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Apurinic/apyrimidinic endonuclease-1 (Ape-1) is involved in base excision repair, cleaving the phosphodiester linkage that is 5’ to the abasic site to produce a single strand break.1 DNA base excision repair pathway inhibitor is a cell-permeable inhibitor of Ape-1 (IC50 = 3-11 µM).1,2,3 Although not toxic to cells by itself at 200 µM, it enhances the cytotoxicity of certain DNA alkylating agents, including temozolomide, when added at this concentration.2 DNA base excision repair pathway inhibitor has little or no effect on radiation-induced cell survival.2,4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-nitro-1H-
CAS Number
6960-45-8
Synonyms
- CRT0044876
- 7-Nitroindole-2-Carboxylic Acid
- NSC 69877
Molecular Formula
C9H6N2O4
Formula Weight
206.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/ml
- DMSO: 5 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
- Ethanol: 0.2 mg/ml
λmax
222, 243, 358 nm
SMILES
OC(C1=CC2=CC=CC([N+]([O-])=O)=C2N1)=O
InChi Code
InChI=1S/C9H6N2O4/c12-9(13)6-4-5-2-1-3-7(11(14)15)8(5)10-6/h1-4,10H,(H,12,13)
InChi Key
BIUCOFQROHIAEO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16348-100 |
|---|---|
| Featured | No |
| Supplier Part Number | 16348-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 6960-45-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |