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Cayman Kb-R7943 (Mesylate); Purity- Greater Than Or Equal To 98%
List Price
$310.00
Your Price
$310.00
Cayman Kb-R7943 (Mesylate); Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16352-50
MFG.PART:
16352-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The Na+/Ca2+ exchanger (NCX) is a major regulator of intracellular calcium concentration that is largely expressed in cardiac sarcolemma (NCX1) but also in brain and skeletal muscle (NCX2). KB-R7943 is an isothiourea derivative that selectively inhibits the reverse mode of NCX1 (IC50 = 1.2-2.4 µM), preventing intracellular sodium-dependent calcium uptake in whole cells.1 It is much less potent at preventing extracellular sodium-dependent calcium efflux from intact cells (IC50 > 30 µM).1 In cultured hippocampal neurons, KB-R7943 exhibits neuroprotection from glutamate-induced excitotoxicity by blocking NMDA receptor-mediated activity (IC50 = 13.4 µM) and inhibiting complex I in the mitochondrial respiratory chain (IC50 = 11.4 µM).2 KB-R7943 has also been shown to block transient receptor potential canonical channels, which are important mediators of calcium-
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
carbamimido
CAS Number
182004-65-5
Molecular Formula
C16H17N3O3S • CH3SO3H
Formula Weight
427.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
223, 269 nm
SMILES
NC(SCCC(C=C1)=CC=C1OCC2=CC=C([N+]([O-])=O)C=C2)=N.OS(C)(=O)=O
InChi Code
InChI=1S/C16H17N3O3S.CH4O3S/c17-16(18)23-10-9-12-3-7-15(8-4-12)22-11-13-1-5-14(6-2-13)19(20)21;1-5(2,3)4/h1-8H,9-11H2,(H3,17,18);1H3,(H,2,3,4)
InChi Key
WGIKEBHIKKWJLG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16352-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 16352-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| CAS Number | 182004-65-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |