We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman UNC0379
List Price
$104.00
Your Price
$104.00
Cayman UNC0379 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16400-10
MFG.PART:
16400-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SET domain-containing protein 8 (SET8) is a methyltransferase that selectively mono-methylates histone H4 at lysine residue 20, an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor. UNC0379 is a substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC50 = 7.3 µM; Kd = 18.3 µM). It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC50s = >100 µM).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-4-quinazolinamine
CAS Number
1620401-82-2
Molecular Formula
C23H35N5O2
Formula Weight
413.6
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 10 mg/mL
λmax
210, 249, 345 nm
SMILES
COC1=C(OC)C=C(N=C(N2CCCC2)N=C3NCCCCCN4CCCC4)C3=C1
InChi Code
InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26)
InChi Key
WEXCGGWTIDNVNT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16400-10 |
|---|---|
| Supplier Part Number | 16400-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1620401-82-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |