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Cayman TNP-470
List Price $191.00 Your Price $191.00
Cayman TNP-470 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16449-10
MFG.PART: 16449-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
TNP-470 is a synthetic analog of fumagillin (Item No. ) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 µM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo.,, It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(2-
CAS Number
129298-91-5
Synonyms
- AGM-1470
- O-(Chloroacetyl-carbamoyl) Fumagillol
- NSC 642492
Molecular Formula
C19H28ClNO6
Formula Weight
401.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 10 mg/mL
SMILES
O=C(NC(CCl)=O)O[C@@H]1CC[C@@]2(OC2)[C@]([C@](O3)(C)[C@H]3C/C=C(C)/C)([H])[C@@H]1OC
InChi Code
InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1
InChi Key
MSHZHSPISPJWHW-PVDLLORBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16449-10 |
|---|---|
| Supplier Part Number | 16449-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 129298-91-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |