Cayman 11 Betaprostaglandin F2 Alpha Ethanolamide; Purity- Grea

AM580 is a retinoic acid receptor agonist that is selective for RARα (K_d = 8 nM; AC₅₀ = 0.36 nM) compared to RARβ (K_d = 131 nM; AC₅₀ = 24.6 nM) and RARγ (K_d = 450 nM; AC₅₀ = 27.9 nM). It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. ), which exhibits little selectivity across RARα, β, or γ.^,, AM580 has been used in combination with the GSK3β inhibitor CHIR99021 (Item No. ) to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm. It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.^,

WARNING This product is not for human or veterinary use.