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Cayman Pladienolide B
List Price $131.00 Your Price $131.00
Cayman Pladienolide B - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16538-100
MFG.PART: 16538-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Spliceosomes mediate the processing of pre-mRNA into mature mRNA., Each spliceosome is a multiunit complex containing several proteins and RNA molecules that work in unison to repeatedly cleave and rejoin segments of mRNA., Pladienolide B is a macrocyclic lactone that selectively binds splicing factor 3b and inhibits mRNA splicing., Through this action, pladienolide B potently blocks the growth of proliferating cells with mean IC50 values of 1.6 nM for six gastric cancer cell lines., In xenograft tumors generated in mice using human cancer cells, pladienolide B blocks mRNA splicing and induces apoptosis, clearing tumors within two weeks after treatment.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(4R,7R,8S,9E,11S,12S)-8-(acetyloxy)-4,7-dihydroxy-12-[(1E,3E,5S)-6-[(2R,3R)-3-[(1R,2S)-2-hydroxy-1-methylbutyl]-2-oxiranyl]-1,5-dimethyl-1,3-oxacyclododec-9-en-2-one
CAS Number
445493-23-2
Molecular Formula
C30H48O8
Formula Weight
536.7
Purity
≥95%
Formulation
A clear film
Solubility
- DMF: Soluble
- DMSO: Soluble
- Ethanol: Soluble
- Methanol: Soluble
λmax
241 nm
SMILES
O[C@H]1CC(O[C@H](/C(C)=C/C=C/[C@@H](C)C[C@@H]2[C@]([C@H](C)[C@H](CC)O)([H])O2)[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC1)=O
InChi Code
InChI=1S/C30H48O8/c1-8-24(33)21(5)29-25(37-29)16-18(2)10-9-11-19(3)28-20(4)12-13-26(36-22(6)31)30(7,35)15-14-23(32)17-27(34)38-28/h9-13,18,20-21,23-26,28-29,32-33,35H,8,14-17H2,1-7H3/b10-9+,13-12+,19-11+/t18-,20+,21-,23-,24+,25-,26+,28-,29-,30-/m1/s1
InChi Key
SDOUORKJIJYJNW-QHOUZYGJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16538-100 |
|---|---|
| Supplier Part Number | 16538-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Australia |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 445493-23-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |