Cayman GPR120 Compound A

GPR120 (free fatty acid receptor 4/FFAR4) is a g protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. It has been linked to the ability of fatty acids to produce anti-inflammatory effects and to acutely potentiate insulin secretion. GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC₅₀ = ~0.35 µM) that demonstrates potent selectivity over another lipid-sensing g-protein, GPR40 (FFAR1). This compound exerts anti-inflammatory effects on macrophages in vitro and improves glucose tolerance, decreases hyperinsulinemia, increases insulin sensitivity, and decreases hepatic steatosis when included at 30 mg/kg body weight in a high-fat diet fed to obese mice.

WARNING This product is not for human or veterinary use.