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Cayman RP 001 (hydrochloride)
List Price $41.00 Your Price $41.00
Cayman RP 001 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16636-1
MFG.PART: 16636-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 9 pM). It is competitive with W146 (Item No. ), a selective S1P1 antagonist, and induces internalization and polyubiquitination of S1P1 in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg). It reduces S1P1-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-[5-[3-
CAS Number
1781880-34-9
Molecular Formula
C24H24N4O4 • HCl
Formula Weight
468.9
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 100 mm
SMILES
OC(CCNC1CCC2=C(C3=NOC(C4=CC(C#N)=C(OC(C)C)C=C4)=N3)C=CC=C21)=O.Cl
InChi Code
InChI=1S/C24H24N4O4.ClH/c1-14(2)31-21-9-6-15(12-16(21)13-25)24-27-23(28-32-24)19-5-3-4-18-17(19)7-8-20(18)26-11-10-22(29)30;/h3-6,9,12,14,20,26H,7-8,10-11H2,1-2H3,(H,29,30);1H
InChi Key
ZHPGSGYEFGEZAL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16636-1 |
|---|---|
| Supplier Part Number | 16636-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1781880-34-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |