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Cayman MK-0752
List Price $479.00 Your Price $479.00
Cayman MK-0752 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16706-10
MFG.PART: 16706-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain.1,2 MK-0752 is a potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells with an IC50 value of 5 nM.3,4 It is orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys.4 Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel (Item No. 11637) in mice with breast cancer tumors.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-cyclohexanepropanoic acid
CAS Number
471905-41-6
Molecular Formula
C21H21ClF2O4S
Formula Weight
442.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 50 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
- Ethanol: 5 mg/mL
λmax
230, 275 nm
SMILES
O=C(O)CC[C@H]1CC[C@](S(C2=CC=C(Cl)C=C2)(=O)=O)(C3=C(F)C=CC(F)=C3)CC1
InChi Code
InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)/t14-,21+
InChi Key
XCGJIFAKUZNNOR-QCKZDCLWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16706-10 |
|---|---|
| Supplier Part Number | 16706-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 471905-41-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |