We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman NSC 348884
List Price $527.00 Your Price $527.00
Cayman NSC 348884 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16716-25
MFG.PART: 16716-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication, and molecular chaperoning. Its activity is dependent on oligomerization at its N-terminal domain, and it is abundantly expressed in tumor and developing cells where it serves to inhibit both cellular differentiation and apoptosis.1 NSC 348884 is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a required binding pocket. It can inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.1,2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N1,N1,N2,N2-
CAS Number
81624-55-7
Molecular Formula
C38H40N10
Formula Weight
636.8
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMF:PBS(pH7.2) (1:2): 0.25 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 1 mg/mL
λmax
247, 281, 287 nm
SMILES
CC(C=C1)=CC2=C1NC(CN(CC3=NC(C=CC(C)=C4)=C4N3)CCN(CC5=NC6=C(C=C(C)C=C6)N5)CC7=NC(C=CC(C)=C8)=C8N7)=N2
InChi Code
InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46)
InChi Key
KZOLQEUQAFTQFM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16716-25 |
|---|---|
| Supplier Part Number | 16716-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Netherlands |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 81624-55-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |