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Cayman AZD 2461
List Price $49.00 Your Price $49.00
Cayman AZD 2461 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16876-1
MFG.PART: 16876-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. AZD 2461 is a PARP inhibitor (IC50 = 5 nM) with low affinity for the P-glycoprotein drug efflux transporter. It was developed to overcome the resistance encountered with olaparib (Item No. ) that is presumed to be mediated in part by P-glycoprotein-mediated drug efflux. When tested on the olaparib-resistant KB1P tumor T6-28, which has an 80-fold increased Mdr1b expression, AZD 2461 did not affect P-glycoprotein. Furthermore, it can induce a loss of p53 binding protein 1 expression in mice with KB1P tumors at 100 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[4-
CAS Number
1174043-16-3
Molecular Formula
C22H22FN3O3
Formula Weight
395.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 3 mg/mL
- DMSO: 2 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 0.5 mg/mL
λmax
277 nm
SMILES
O=C1C2=CC=CC=C2C(CC3=CC(C(N4CCC(OC)CC4)=O)=C(F)C=C3)=NN1
InChi Code
InChI=1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27)
InChi Key
HYNBNUYQTQIHJK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16876-1 |
|---|---|
| Supplier Part Number | 16876-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1174043-16-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |