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Cayman NSC 632839
List Price $103.00 Your Price $103.00
Cayman NSC 632839 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16893-5
MFG.PART: 16893-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 µM, respectively.1 It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 µM in cells sensitized by E1A, an adenoviral oncogene).2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3,5-bis[(4-methylphenyl)methylene]-4-piperidinone, monohydrochloride
CAS Number
157654-67-6
Synonyms
- F6
- Ubiquitin Isopeptidase Inhibitor II
Molecular Formula
C21H21NO • HCl
Formula Weight
339.9
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 0.25 mg/mL
λmax
240, 345 nm
SMILES
CC1=CC=C(/C=C2C(/C(CNC\2)=C\C3=CC=C(C)C=C3)=O)C=C1.Cl
InChi Code
InChI=1S/C21H21NO.ClH/c1-15-3-7-17(8-4-15)11-19-13-22-14-20(21(19)23)12-18-9-5-16(2)6-10-18;/h3-12,22H,13-14H2,1-2H3;1H/b19-11-,20-12-;
InChi Key
ZOKZLTXPTLIWOJ-GRVJEYRUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16893-5 |
|---|---|
| Supplier Part Number | 16893-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 157654-67-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |