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Cayman BRL 50481
List Price $86.00 Your Price $86.00
Cayman BRL 50481 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16899-10
MFG.PART: 16899-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM. It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5. Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects of the PDE4 blocker rolipram (Item No. ) on monocytes, lung macrophages, and CD8+ T-lymphocytes. BRL 50481, at 30 µM, promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B, suggesting that this compound also acts against PDE7B. BRL 50481 can be used to evaluate the role of PDE7 isoforms in intracellular signaling.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N,N,2-
CAS Number
433695-36-4
Molecular Formula
C9H12N2O4S
Formula Weight
244.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMF:PBS (pH7.2) (1:40): 0.02 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 15 mg/mL
λmax
210, 265 nm
SMILES
CC1=C(S(N(C)C)(=O)=O)C=C([N+]([O-])=O)C=C1
InChi Code
InChI=1S/C9H12N2O4S/c1-7-4-5-8(11(12)13)6-9(7)16(14,15)10(2)3/h4-6H,1-3H3
InChi Key
IFIUFCJFLGCQPH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16899-10 |
|---|---|
| Supplier Part Number | 16899-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 433695-36-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |