Cayman Bg45; Purity- Greater Than Or Equal To 95%; Size- 5 Mg

SC144 is an orally bioavailable gp130 inhibitor. It inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells when used at a concentration of 20 µM. SC144 induces cell cycle arrest at the G₀/G₁ phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines, including prostate, ovarian, lung, breast, and colorectal cancer cells, with IC₅₀ values ranging from 0.4 to 4 µM. It reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.^,

WARNING This product is not for human or veterinary use.