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Cayman Indoxyl Sulfate (potassium salt)
List Price
$215.00
Your Price
$215.00
Cayman Indoxyl Sulfate (potassium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16926-1
MFG.PART:
16926-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan (Item No. ). It is formed via sulfation of indoxyl, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver., Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mm) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1H-indol-3-ol, 3-(hydrogen sulfate), monopotassium salt
CAS Number
2642-37-7
Molecular Formula
C8H6NO4S • K
Formula Weight
251.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
221, 281 nm
SMILES
[O-]S(OC1=CNC2=CC=CC=C21)(=O)=O.[K+]
InChi Code
InChI=1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8;/h1-5,9H,(H,10,11,12);/q;+1/p-1
InChi Key
MDAWATNFDJIBBD-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16926-1 |
|---|---|
| Supplier Part Number | 16926-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2642-37-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |