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Cayman Glycochenodeoxycholic Acid (sodium salt hydrate)
List Price $53.00 Your Price $53.00
Cayman Glycochenodeoxycholic Acid (sodium salt hydrate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16942-50
MFG.PART: 16942-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Glycochenodeoxycholic acid (GCDCA) is a glycine-conjugated form of the primary bile acid chenodeoxycholic acid (Item No. 10011286).1 It reduces formation of cholic acid (Item No. 20250) in primary human hepatocytes when used at a concentration of 100 µM.2 GCDCA (50, 75, and 100 µM) reduces the number of LC3 puncta, a marker of autophagy, and is cytotoxic to L-02 hepatocytes.1 GCDCA (50 µM) induces apoptosis in isolated rat hepatocytes, an effect that can be blocked by the protein kinase C (PKC) inhibitor chelerythrine (Item No. 11314).3 Fecal levels of GCDCA are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(3α,5β,7α)-
Synonyms
- GCDCA
- NSC 681056
Molecular Formula
C26H42NO5 • Na [XH2O]
Formula Weight
471.6
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 15 mg/mL
- PBS (pH 7.2): 1 mg/mL
SMILES
O[C@@H]1CC[C@@]2(C)[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCC([O-])=O)=O)([H])C1.[Na+].O
InChi Code
InChI=1S/C26H43NO5.Na.H2O/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29;;/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;1H2/q;+1;/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-;;/m1../s1
InChi Key
DPKVEQOULFKWCR-KZRRTRIISA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16942-50 |
|---|---|
| Supplier Part Number | 16942-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |