Cayman ()-Gallocatechin; Purity- Greater Than Or Equal To 98%; Si

Boldine is an alkaloid that has been found in P. boldus and has diverse biological activities.^,,, It completely inhibits tert-butyl hydroperoxide-induced lipid peroxidation and cell death in isolated rat hepatocytes when used at a concentration of 200 µM. Boldine reduces copper- and peroxidase-induced LDL oxidation in vitro in a concentration-dependent manner. In vivo, boldine (1 mg/animal per day) reduces the number and area of aortic atherosclerotic lesions in LDL receptor knockout (LDLR^-/-) mice fed an atherogenic diet. It reduces carrageenan-induced paw edema in guinea pigs (ED₅₀ = 43 mg/kg) and reduces bacterial pyrogen-induced hyperthermia in rabbits when administered at a dose of 60 mg/kg. Boldine (25 and 50 mg/kg) increases the latency to myoclonic and clonic seizures in a mouse model of seizures induced by pentylenetetrazole (PTZ; Item No. 18682). It also decreases electroshock-induced tonic hindlimb extension in mice.

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