We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman AZD 8055
List Price
$143.00
Your Price
$143.00
Cayman AZD 8055 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16978-10
MFG.PART:
16978-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
AZD 8055 is a potent, selective ATP-competitive inhibitor of mTOR, exhibiting an IC50 value of 0.8 nM.1 It is ~1,000-fold selective for mTOR over all PI3K isoforms and exhibits no activity against a panel of 260 kinases at concentrations up to 10 µM. AZD 8055 inhibits proliferation of A549 and H838 cells with IC50 values of 53 and 20 nM, respectively. It inhibits growth of a variety of human tumor xenografts by at least 65% in mice at daily oral doses of 20 mg/kg.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-benzenemethanol
CAS Number
1009298-09-2
Synonyms
- CCG-168
Molecular Formula
C25H31N5O4
Formula Weight
465.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 1 mg/mL
- Ethanol: 0.5 mg/mL
λmax
211, 229, 281, 387 nm
SMILES
C[C@@H](COCC1)N1C2=NC(N3[C@@H](C)COCC3)=C(C=CC(C4=CC(CO)=C(OC)C=C4)=N5)C5=N2
InChi Code
InChI=1S/C25H31N5O4/c1-16-14-33-10-8-29(16)24-20-5-6-21(18-4-7-22(32-3)19(12-18)13-31)26-23(20)27-25(28-24)30-9-11-34-15-17(30)2/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17-/m0/s1
InChi Key
KVLFRAWTRWDEDF-IRXDYDNUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16978-10 |
|---|---|
| Supplier Part Number | 16978-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1009298-09-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |