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Cayman Binimetinib
List Price $481.00 Your Price $481.00
Cayman Binimetinib - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16996-50
MFG.PART: 16996-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Binimetinib is a MEK1 and MEK2 inhibitor (IC50s = 1.8 and 0.92 nM, respectively).1 It is selective for MEK1/2 over a panel of RAF/MEK/ERK pathway kinases at 10 µM. Binimetinib reduces cell growth in HT-29, COLO 205, and LoVo colorectal cancer cell lines (IC50s = 0.48, 0.52, and 2.2 nM, respectively). It reduces tumor volume in a COLO 205 mouse xenograft model when administered at a dose of 0.3 mg/kg. Formulations containing binimetinib have been used in the treatment of various cancers.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[(4-bromo-
CAS Number
606143-89-9
Synonyms
- ARRY-438162
- MEK162
Molecular Formula
C17H15BrF2N4O3
Formula Weight
441.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 0.5 mg/mL
λmax
213, 257 nm
SMILES
BrC1=CC(F)=C(NC2=C(F)C(N=CN3C)=C3C=C2C(NOCCO)=O)C=C1
InChi Code
InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChi Key
ACWZRVQXLIRSDF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16996-50 |
|---|---|
| Supplier Part Number | 16996-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 606143-89-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |