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Cayman BIX02189
List Price $231.00 Your Price $231.00
Cayman BIX02189 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16999-10
MFG.PART: 16999-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively), preventing transcriptional activation of the downstream target MEF2C. It minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2. BIX02189 blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells. It has been used to investigate the roles of MEK5/ERK5 signaling in nerve growth factor-mediated neurite outgrowth and myeloid cell differentiation.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3Z)-3-[[[3-
CAS Number
1265916-41-3
Molecular Formula
C27H28N4O2
Formula Weight
440.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 15 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 10 mg/mL
λmax
284, 385 nm
SMILES
CN(C)CC1=CC(N/C(C2=CC=CC=C2)=C3C(NC4=C\3C=CC(C(N(C)C)=O)=C4)=O)=CC=C1
InChi Code
InChI=1S/C27H28N4O2/c1-30(2)17-18-9-8-12-21(15-18)28-25(19-10-6-5-7-11-19)24-22-14-13-20(27(33)31(3)4)16-23(22)29-26(24)32/h5-16,28H,17H2,1-4H3,(H,29,32)/b25-24-
InChi Key
HOMJAAIVTDVQJA-IZHYLOQSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16999-10 |
|---|---|
| Supplier Part Number | 16999-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1265916-41-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |