Cayman BB-Cl-Amidine (trifluoroacetate salt)

BB-Cl-amidine is a pan inhibitor of peptidyl arginine deiminases (PADs) and a proteolysis-resistant derivative of Cl-amidine (Item No. ). It irreversibly inhibits PAD1-4 (k_inact/K_I = 16,100, 4,100, 6,800, and 13,300 M^-1min^-1, respectively).^, BB-Cl-amidine (20 and 200 µM) inhibits the formation of neutrophil extracellular traps (NETs) induced by phorbol 12-myristate 13-acetate (PMA; Item No. ) without altering hydrogen peroxide (H₂O₂) production in bone marrow-derived neutrophils. It inhibits IFN-β production induced by the DNA virus herpes simplex virus 1 (HSV-1) but not the RNA virus Sendai virus in mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 1 µM. Ex vivo, BB-Cl-amidine (10 mg/kg) reduces BMDM IFN-β and TNF-α production induced by diABZI STING agonist-1 (Item No. ) in wild-type, Pad2^-/-, and Pad4^-/- mice. BB-Cl-amidine (20 mg/kg per day) increases survival, as well as reduces splenomegaly, myocarditis, and cardiac fibrosis in a Trex1^D18N/D18N mouse model of Aicardi-Goutières syndrome (AGS).

WARNING This product is not for human or veterinary use.