Cayman Cu-ATSM

Cu-ATSM is a copper-containing compound with diverse biological activities.^1,2,3 It inhibits ferroptotic cell death induced by RSL3, erastin (Item No. 17754), or iron(II) (EC₅₀s = 134, 169, and 171 nM, respectively), as well as RSL3-, erastin-, or iron-induced lipid peroxidation in N27 rat mesencephalic cells when used at a concentration of 1 µM.¹ Cu-ATSM (30 mg/kg per day) increases mutant superoxide dismutase (SOD1^G37R) protein levels, metalation, and activity in the spinal cord in the SOD1^G37R transgenic mouse model of amyotrophic lateral sclerosis (ALS).² It also increases the number of α-motor neurons and reduces oxidatively modified proteins in the spinal cord, as well as increases the latency to fall in the rotarod test in the same ALS mouse model. Cu-ATSM containing positron-emitting copper isotopes has been used in PET imaging applications for selective labeling of hypoxic tissue.³

WARNING This product is not for human or veterinary use.