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Cayman 8-pCPT-2-O-methyl Cyclic AMP
List Price $236.00 Your Price $236.00
Cayman 8-pCPT-2-O-methyl Cyclic AMP - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17143-1
MFG.PART: 17143-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2’-O-methyl Cyclic AMP (8-pCPT-2′-O-Me-cAMP) is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM). It is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP., 8-pCPT-2′-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA. It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function.,,,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
8-[(4-
CAS Number
634207-53-7
Synonyms
- 8-CPT-2-methyl cAMP
- 8-CPT-2-methyl Cyclic adenosine monophosphate
- 8-pCPT cAMP
- 8-pCPT Cyclic adenosine monophosphate
- 8-pCPT Cyclic AMP
- 8-pCPT-2-O-methyl cAMP
- 8-pCPT-2-O-methyl Cyclic adenosine monophosphate
Molecular Formula
C17H16N5O6ClPS • Na
Formula Weight
507.8
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 0.5 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
210, 224, 283 nm
SMILES
O=P1([O-])O[C@H]2[C@@H](OC)[C@H](N3C(SC4=CC=C(Cl)C=C4)=NC5=C3N=CN=C5N)O[C@@H]2CO1.[Na+]
InChi Code
InChI=1S/C17H17ClN5O6PS.Na/c1-26-13-12-10(6-27-30(24,25)29-12)28-16(13)23-15-11(14(19)20-7-21-15)22-17(23)31-9-4-2-8(18)3-5-9;/h2-5,7,10,12-13,16H,6H2,1H3,(H,24,25)(H2,19,20,21);/q;+1/p-1/t10-,12-,13-,16-;/m1./s1
InChi Key
VHTMKTNUXDACHB-KHXPSBENSA-M
License
Protected by Patent No. EP 02077219.0 and foreign equivalents. Exclusively licensed to BIOLOG Life Science Institute for research purposes only.
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17143-1 |
|---|---|
| Supplier Part Number | 17143-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Germany |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 634207-53-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |