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Cayman ADAMTS-5 Inhibitor
List Price $98.00 Your Price $98.00
Cayman ADAMTS-5 Inhibitor - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17188-1
MFG.PART: 17188-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes., ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[[5-[[(4-chlorophenyl)methyl]thio]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene]-2-thioxo-4-thiazolidinone
CAS Number
929634-33-3
Molecular Formula
C16H11ClF3N3OS3
Formula Weight
449.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 20 mg/mL
λmax
225, 280, 363 nm
SMILES
ClC1=CC=C(CSC2=C(/C=C3C(NC(S/3)=S)=O)C(C(F)(F)F)=NN2C)C=C1
InChi Code
InChI=1S/C16H11ClF3N3OS3/c1-23-14(26-7-8-2-4-9(17)5-3-8)10(12(22-23)16(18,19)20)6-11-13(24)21-15(25)27-11/h2-6H,7H2,1H3,(H,21,24,25)/b11-6-
InChi Key
CVYPRDPBCXSVBN-WDZFZDKYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17188-1 |
|---|---|
| Supplier Part Number | 17188-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Netherlands |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 929634-33-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |