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Cayman 4-Methylumbelliferyl- Betad-Glucuronide (Hydrate); Purit
List Price
$456.00
Your Price
$456.00
Cayman 4-Methylumbelliferyl- Beta -D-Glucuronide (Hydrate); Purity- Greater Than Or Equal To 95%; Size- 5 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17203-5
MFG.PART:
17203-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TMP-195 is an inhibitor of class IIa histone deacetylases (HDACs; Kis = 59, 60, 26, and 15 nM for HDAC4, 5, 7, and 9, respectively). It is selective for class IIa HDACs over class I and class IIb HDACs (Kis = 10-43 μM for HDAC1-3, 6, 9, and 10-11). TMP-195 blocks accumulation of chemoattractant chemokine ligand 2 (CCL2) in the supernatant of monocytes stimulated with macrophage colony-stimulating factor (CSF-1). It increases secretion of CCL1 by monocytes stimulated with CSF-1 and granulocyte/monocyte colony-stimulating factor (GM-CSF). In vivo, TMP-195 reduces tumor burden and the number of pulmonary metastases in a macrophage-dependent autochthonous mouse model of breast cancer.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[2-methyl-
CAS Number
1314891-22-9
Molecular Formula
C23H19F3N4O3
Formula Weight
456.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 10 mg/ml
- PBS (pH 7.2): 0.2 mg/ml
λmax
209, 270 nm
SMILES
O=C(NCC(C)(C1=COC(C2=CC=CC=C2)=N1)C)C3=CC(C4=NOC(C(F)(F)F)=N4)=CC=C3
InChi Code
InChI=1S/C23H19F3N4O3/c1-22(2,17-12-32-20(28-17)14-7-4-3-5-8-14)13-27-19(31)16-10-6-9-15(11-16)18-29-21(33-30-18)23(24,25)26/h3-12H,13H2,1-2H3,(H,27,31)
InChi Key
QTCSXAUJBQZZSN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17203-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 17203-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |