Cayman 4-Methylumbelliferyl- Betad-Glucuronide (Hydrate); Purit

Maresin conjugates in tissue regeneration 2 (MCTR2) is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. ) in macrophages at the site of inflammation.^, DHA is oxidized to maresin 1 (MaR1; Item No. ), which is converted to MCTR1 (Item No. ) by glutathione S-transferase Mu 4 or leukotriene C₄ synthase then to MCTR2 by γ-glutamyl transferase. MCTR2 accelerates tissue regeneration in planaria (1 and 100 nM). Pretreatment with MCTR2 prior to E. coli administration reduces neutrophil infiltration, shortens the inflammatory resolution period, and increases phagocytosis of E. coli by macrophages. When administered at a dose of 100 ng 12h post E. coli infection in a mouse model of peritonitis, MCTR2 selectively reduced the amount of the eicosanoids PGD₂ (Item No. ) and PGF_2α (Item No. ) in the exudate.

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