Cayman Bpiq-I; Purity- Greater Than Or Equal To 95%; Size- 5 Mg;

Erastin, named for eradicator of RAS and small T (ST) antigen-expressing cells, is a ferroptosis inducer. It induces ferroptotic cell death in vitro, an effect that can be blocked by the ferroptosis inhibitors ciclopirox olamine, Trolox (Item No. ), ferrostatin-1 (Item No. ), U-0126 (Item No. ), cycloheximide (Item No. ), and β-mercaptoethanol. Erastin (5 µM) inhibits cystine uptake by the system x_c^- cystine-glutamate transporter in HT-1080 fibrosarcoma and Calu-1 lung carcinoma cells and inhibits glutamate release in an enzyme-coupled fluorescence assay (EC₅₀ = 1.2 µM). It also selectively induces cell death in cells expressing the SV40 small T oncoprotein and oncogenic Ras (IC₅₀s = 1.25-5 µg/ml).

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