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Cayman Toll-Like Receptor 7 Ligand Ii; Purity- Greater Than Or Eq
List Price
$153.00
Your Price
$153.00
Cayman Toll-Like Receptor 7 Ligand Ii; Purity- Greater Than Or Equal To 98%; Size- 500 Micrograms; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17228-500
MFG.PART:
17228-500
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors. AG-879 is a tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Additionally, AG-879 inhibits the activation of ETK with an IC50 value of ~5 nM, which blocks tyrosine phosphorylation of PAK1, suppressing Ras transformation of NIH 3T3 fibroblasts. AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC50 = 15 μM) in schwannoma cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-
CAS Number
148741-30-4
Synonyms
- Tyrphostin AG-
879
Molecular Formula
C18H24N2OS
Formula Weight
316.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:5): 0.17 mg/ml
- Ethanol: 10 mg/ml
λmax
203, 248, 355, 377, 498 nm
SMILES
CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C(N)=S)\C#N)=C1
InChi Code
InChI=1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
InChi Key
XRZYELWZLNAXGE-KPKJPENVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17228-500 |
|---|---|
| Featured | No |
| Supplier Part Number | 17228-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 226907-52-4 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |