We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Pk7242 (Maleate); Purity- Greater Than Or Equal To 95%; Si
List Price
$412.00
Your Price
$412.00
Cayman Pk7242 (Maleate); Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17230-5
MFG.PART:
17230-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Leniolisib is an inhibitor of PI3Kδ (IC50 = 0.011 µM). It is selective for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ (IC50s = 0.244, 0.424, and 2.23 µM, respectively). It inhibits phosphorylation of the PI3K target Akt in Rat-1 fibroblasts expressing P13K p110δ with an IC50 value of 0.056 µM. Leniolisib inhibits the mixed lymphocyte reaction (MLR), indicating inhibition of allogeneic T cell activation, in isolated human peripheral blood mononuclear cells (PBMCs) and isolated mouse splenocytes (IC50s = 0.079 and 0.033 µM, respectively). It also inhibits PI3Kδ-dependent B cell activation and IgM-induced B cell proliferation in isolated mouse splenocytes. Leniolisib (3 and 10 mg/kg) reduces the production of rat anti-rat collagen antibodies, as well as reduces paw swelling and joint erosion in a rat model of collagen-induced arthritis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[(3S)-3-
CAS Number
1354690-24-6
Synonyms
- CDZ 173
Molecular Formula
C21H25F3N6O2
Formula Weight
450.5
Purity
≥98% (mixture of rotamers)
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 20 mg/ml
λmax
248 nm
SMILES
COC1=NC=C(N2CC(C(N[C@H]3CCN(C(CC)=O)C3)=NC=N4)=C4CC2)C=C1C(F)(F)F
InChi Code
InChI=1S/C21H25F3N6O2/c1-3-18(31)30-6-4-13(10-30)28-19-15-11-29(7-5-17(15)26-12-27-19)14-8-16(21(22,23)24)20(32-2)25-9-14/h8-9,12-13H,3-7,10-11H2,1-2H3,(H,26,27,28)/t13-/m0/s1
InChi Key
MWKYMZXCGYXLPL-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17230-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 17230-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |