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Cayman Mtsea-Biotin; Purity- Greater Than Or Equal To 95%; Size-
List Price
$139.00
Your Price
$139.00
Cayman Mtsea-Biotin; Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17237-5
MFG.PART:
17237-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Zardaverine is a dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 (IC50s = 0.617 and 1.738 μM, respectively, for the rat cardiac ventricle enzymes). It is selective for PDE3 and PDE4 over PDE1B, PDE2, and PDE5 (IC50s = >138 μM for all). Zardaverine inhibits aggregation of human platelets induced by ADP (Item No. ), platelet-activating factor (PAF), collagen, arachidonic acid (Item Nos. | | ), or prostaglandin E1 (PGE1; Item No. ) and ADP (IC50s = 1.5-16.2 μM). It inhibits zymosan-induced superoxide anion release from human polymorphonuclear (PMN) cells (IC50 = 0.4 μM). Zardaverine (10 μmol/kg) decreases lung resistance and increases dynamic compliance in a rat model of acetylcholine-induced bronchospasm. It decreases the viability of HeLa, COLO 741, NCI H2122, and A2058 cells that endogenously express high levels of PDE3A (IC50s = 0.032, 0.027, 0.26, and 0.13 μM, respectively), but is inactive against a panel of eight cancer cell lines that express low levels of PDE3A (IC50s = >16 μM for all).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[4-
CAS Number
101975-10-4
Molecular Formula
C12H10F2N2O3
Formula Weight
268.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 100mM
λmax
255 nm
SMILES
FC(F)OC1=CC=C(C2=NNC(C=C2)=O)C=C1OC
InChi Code
InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17)
InChi Key
HJMQDJPMQIHLPB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17237-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 17237-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 162758-04-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |