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Cayman VER-155008
List Price $801.00 Your Price $801.00
Cayman VER-155008 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17257-50
MFG.PART: 17257-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 µM) that is selective over Hsp90.1 It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 µM) and glucose-regulated protein 78 (Grp78; KD = 80 nM).2,3 VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death.4 It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors.1,4 VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-O-[(4-cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine
CAS Number
1134156-31-2
Molecular Formula
C25H23Cl2N7O4
Formula Weight
556.4
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:9): 0.1 mg/mL
λmax
216, 275 nm
SMILES
O[C@H]1[C@@H](O)[C@H](N2C(NCC3=CC=C(Cl)C(Cl)=C3)=NC4=C2N=CN=C4N)O[C@@H]1COCC5=CC=C(C#N)C=C5
InChi Code
InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1
InChi Key
ZXGGCBQORXDVTE-UMCMBGNQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17257-50 |
|---|---|
| Supplier Part Number | 17257-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1134156-31-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |