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Cayman Eht 1864; Purity- Greater Than Or Equal To 98%; Size- 50 M
List Price
$911.00
Your Price
$911.00
Cayman Eht 1864; Purity- Greater Than Or Equal To 98%; Size- 50 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17258-50
MFG.PART:
17258-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
EHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively.1 It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras.1 EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation.2 It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 µM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.3,4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one, dihydrochloride
CAS Number
754240-09-0
Molecular Formula
C25H27F3N2O4S • 2HCl
Formula Weight
581.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 50 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- PBS (pH 7.2): 10 mg/ml
λmax
221, 317, 329 nm
SMILES
O=C1C(OCCCCCSC2=CC=NC3=C2C=CC(C(F)(F)F)=C3)=COC(CN4CCOCC4)=C1.Cl.Cl
InChi Code
InChI=1S/C25H27F3N2O4S.2ClH/c26-25(27,28)18-4-5-20-21(14-18)29-7-6-24(20)35-13-3-1-2-10-33-23-17-34-19(15-22(23)31)16-30-8-11-32-12-9-30;;/h4-7,14-15,17H,1-3,8-13,16H2;2*1H
InChi Key
LSECOAJFCKFQJG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17258-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 17258-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 754240-09-0 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |