Cayman Ag957; Purity- Greater Than Or Equal To 95%; Size- 10 Mg;

Tyrphostins are tyrosine phosphorylation inhibitors that act by inhibiting tyrosine kinases.¹ AG957 is a tyrphostin that targets transforming Bcr-Abl fusion proteins (p185^Bcr-Abl, p210^Bcr-Abl), as well as normal c-Abl (IC₅₀s = 4.3, 1, and 7.1 µM, respectively, for human proteins).² It also inhibits epidermal growth factor receptor (IC₅₀ = 0.25 µM).² As the constitutively-active 210 kDa Bcr-Abl fusion protein commonly occurs in chronic myelogenous leukemia (CML) cells, AG957 is commonly used to study Bcr-Abl signaling in the CML K562 cell line.^3,4 AG957 is also used to study signaling through c-Abl.⁵

WARNING This product is not for human or veterinary use.