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Cayman Pd 145305; Purity- Greater Than Or Equal To 95%; Size- 1 M
List Price
$43.00
Your Price
$43.00
Cayman Pd 145305; Purity- Greater Than Or Equal To 95%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17261-1
MFG.PART:
17261-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Clemastine is a histamine H1 receptor antagonist (Ki = 0.26 nM). It is selective for the histamine H1 receptor over muscarinic acetylcholine receptors (mAChRs; Ki = 16 nM), as well as over sigma-1 (σ1) and σ2 and α2A-, α2B-, and α2C-adrenergic receptors (Kis = 67, 15, 1,365, 691, and 545 nM, respectively)., Clemastine (0.12 mg/kg) alone or in combination with the histamine H2 receptor antagonist cimetidine (Item No. ) reduces ovalbumin-induced bronchial obstruction in ovalbumin-sensitized guinea pigs. It also decreases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 0.95 µM) with a 50% cytotoxic concentration (CC50) value of >20 µM. Formulations containing clemastine have been used in the treatment of allergic rhinitis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2R)-2-[2-
CAS Number
14976-57-9
Molecular Formula
C21H26ClNO • C4H4O4
Formula Weight
460.0
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 1.6 mg/ml
- DMSO: 2.5 mg/ml
- Ethanol: 0.1 mg/ml
- PBS (pH 7.2): 0.3 mg/ml
SMILES
ClC1=CC=C([C@@](OCC[C@H]2CCCN2C)(C)C3=CC=CC=C3)C=C1.OC(/C=C/C(O)=O)=O
InChi Code
InChI=1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
InChi Key
PMGQWSIVQFOFOQ-YKVZVUFRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17261-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 17261-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| CAS Number | 90536-15-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |