Cayman Nu 6140; Purity- Greater Than Or Equal To 98%; Size- 5 Mg

Calcitriol-d₆ is intended for use as an internal standard for the quantification of calcitriol (Item No. ) by GC- or LC-MS. Calcitriol is a vitamin D₃ receptor agonist and an active metabolite of vitamin D₃ (Item No. ).^, It is formed via a multi-step process, in which vitamin D₃ undergoes hydroxylation to 25-hydroxy vitamin D₃ (Item No. ) in the liver, followed by further hydroxylation at the 1α-position in the kidney. Calcitriol binds to the vitamin D₃ receptor (K_d = 16 pM) and induces differentiation of U937 acute monocytic leukemia cells (EC₅₀ = 2,000 pM). It induces cell cycle arrest at the S phase and apoptosis in primary adenomatous and hyperplastic human parathyroid cells when used at a concentration of 10 nM. Calcitriol (0.65 nmol/animal) increases bone calcium mobilization in chicks on a low-calcium diet. It stimulates calcium absorption in the intestines in a chick model of rickets induced by a vitamin D₃-deficient diet when administered at a dose of 25 µg/animal. Formulations containing calcitriol have been used in the treatment of hypocalcemia.

WARNING This product is not for human or veterinary use.