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Cayman Taurolithocholic Acid (sodium salt)
List Price
$160.00
Your Price
$160.00
Cayman Taurolithocholic Acid (sodium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17275-50
MFG.PART:
17275-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Taurolithocholic acid (TLCA) is a taurine-conjugated form of the secondary bile acid lithocholic acid (Item No. 20253).1 TLCA (75 μM) increases caspase-3 and -7 activity in Hep3B cells transfected with sodium taurocholate cotransporting peptide (NTCP), but not nontransfected Hep3B cells.2 It has been used to induce cholestasis in ex vivo and in vivo animal models of hepatocellular cholestasis.3,4 Serum levels of TLCA increase approximately 5-fold in within two hours during an oral lipid tolerance test in humans.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
CAS Number
6042-32-6
Synonyms
- NSC 681057
- Sodium taurolithocholate
- TLCA
Molecular Formula
C26H44NO5S • Na
Formula Weight
505.7
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 1 mg/mL
- PBS (pH 7.2): 1 mg/mL
SMILES
O=C(NCCS([O-])(=O)=O)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
InChi Code
InChI=1S/C26H45NO5S.Na/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3;/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32);/q;+1/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-;/m1./s1
InChi Key
YAERYJYXPRIDTO-HRHHVWJRSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17275-50 |
|---|---|
| Supplier Part Number | 17275-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 6042-32-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |