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Cayman Necrox-5 (methanesulfonate)
List Price
$128.00
Your Price
$128.00
Cayman Necrox-5 (methanesulfonate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17278-1
MFG.PART:
17278-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity. It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP). This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate
CAS Number
1383718-29-3
Synonyms
- Necrosis Inhibitor 5
- NecroX-5
Molecular Formula
C25H31N3O3S • 2CH4O3S
Formula Weight
645.8
Purity
≥85%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMF:PBS(pH 7.2)(1:6): 0.1 mg/mL
- DMSO: 1 mg/mL
- Ethanol: 0.25 mg/mL
λmax
209, 275, 311 nm
SMILES
O=S(CCN1CC2=CC(NCC3CCOCC3)=C(NC(C4=CC=CC=C4)=C5)C5=C2)(CC1)=O.OS(C)(=O)=O.OS(C)(=O)=O
InChi Code
InChI=1S/C25H31N3O3S.2CH4O3S/c29-32(30)12-8-28(9-13-32)18-20-14-22-16-23(21-4-2-1-3-5-21)27-25(22)24(15-20)26-17-19-6-10-31-11-7-19;2*1-5(2,3)4/h1-5,14-16,19,26-27H,6-13,17-18H2;2*1H3,(H,2,3,4)
InChi Key
ZWWWDIWEZYRVMB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-17278-1 |
|---|---|
| Supplier Part Number | 17278-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1383718-29-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |