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Cayman O-Dianisidine (Hydrochloride); Purity- Greater Than Or Equ
List Price
$44.00
Your Price
$44.00
Cayman O-Dianisidine (Hydrochloride); Purity- Greater Than Or Equal To 98%; Size- 5 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17316-5
MFG.PART:
17316-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Peficitinib is an inhibitor of JAK (IC50s = 3.9, 5, and 0.71 nM for JAK1-3, respectively). It is 14-fold selective for JAK1 and JAK3 over JAK2 in erythropoietin-induced leukemia cell proliferation assays. Peficitinib inhibits IL-2-induced proliferation of rat splenocytes (IC50 = 10 nM) and phosphorylation of STAT5 in rat and human whole blood (IC50s = 124 and 127 nM, respectively). In vivo, peficitinib reduces paw swelling (ED50 = 5.6 mg/kg) and bone destruction in a rat model of adjuvant-induced arthritis when administered at a dose of 30 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(5-
CAS Number
944118-01-8
Synonyms
- ASP015K
- JNJ-54781532
Molecular Formula
C18H22N4O2
Formula Weight
326.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 1 mg/ml
λmax
246, 294 nm
SMILES
NC(C1=CN=C2C(C=CN2)=C1N[C@@H]3[C@H](C4)C[C@@]5(O)C[C@@H]3C[C@@H]4C5)=O
InChi Code
InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9-,10-,11+,14-,18-
InChi Key
DREIJXJRTLTGJC-ZKVNVPQCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17316-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 17316-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 20325-40-0 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |