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Cayman Spiro-Meotad; Purity- Greater Than Or Equal To 95%; Size-
List Price
$138.00
Your Price
$138.00
Cayman Spiro-Meotad; Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17317-10
MFG.PART:
17317-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity. This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-4-methyl-pentanamide
CAS Number
208663-26-7
Synonyms
- Matrix Metalloproteinase-3 Inhibitor VIII
- Stromelysin-1 Inhibitor VIII
Molecular Formula
C20H26N2O5S
Formula Weight
406.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 10 mg/ml
λmax
245 nm
SMILES
COC1=CC=C(S(N(CC2=CC=CC=C2)C(CC(C)C)C(NO)=O)(=O)=O)C=C1
InChi Code
InChI=1S/C20H26N2O5S/c1-15(2)13-19(20(23)21-24)22(14-16-7-5-4-6-8-16)28(25,26)18-11-9-17(27-3)10-12-18/h4-12,15,19,24H,13-14H2,1-3H3,(H,21,23)
InChi Key
VKUYLANQOAKALN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17317-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 17317-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 207739-72-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |