Cayman Tetrazolium (Chloride); Purity- Greater Than Or Equal To 9

TAK-715 is an inhibitor of p38α MAPK (IC₅₀ = 7.1 nM). It is selective for p38α over p38β (IC₅₀ = 200 nM), as well as over p38γ/δ, JNK, ERK1, IKKβ, MEKK1, and TAK1 (IC₅₀ = >10 µM for all) but also inhibits casein kinase Iδ (CK1δ) and CK1ε.^, It inhibits TNF-α release induced by LPS from THP-1 cells (IC₅₀ = 48 nM) and inhibits LPS-induced TNF-α production by 87.6% in mice when administered at a dose of 10 mg/kg. TAK-715 (30 mg/kg) reduces adjuvant-induced paw swelling in a rat model of rheumatoid arthritis. It also inhibits phosphorylation of human Disheveled 2 (hDvl2) by Wnt3a in a p38α-independent manner.

WARNING This product is not for human or veterinary use.