Cayman Chlorhexidine (hydrochloride)

Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent.¹ It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC₉₀ = 4 μg/mL).² It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC₉₀s = 4, 2, 2, and 1 mg/L, respectively).³ Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/mL) and C. albicans (MIC = 5.15 μg/mL).^4,5 It generates cations that bind to and destabilize the bacterial cell wall to induce death.⁶ Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay.⁷ Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.

WARNING This product is not for human or veterinary use.