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Cayman Reparixin
List Price
$29.00
Your Price
$29.00
Cayman Reparixin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17350-1
MFG.PART:
17350-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Reparixin is an allosteric antagonist of chemokine (C-X-C motif) receptor 1 (CXCR1) and CXCR2 (IC50s = 1 and 100 nM, respectively). In vivo, reparixin (3, 15, and 30 mg/kg) reduces ischemia and reperfusion-induced hepatic polymorphonuclear leukocyte (PMN) recruitment, hepatic myeloperoxidase (MPO) levels, and serum alanine transaminase (ALT) levels in a rat model of hepatic ischemia. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 5 mg/kg. Reparixin, in combination with docetaxel (Item No. ), reduces tumor volume and the number of intratumor cancer stem cells in a SUM159 triple-negative breast cancer (TNBC) mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(αR)-α-
CAS Number
266359-83-5
Synonyms
- DF 1681Y
- Repertaxin
Molecular Formula
C14H21NO3S
Formula Weight
283.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 25 mg/mL
- PBS (pH 7.2): 0.2 mg/mL
λmax
220 nm
SMILES
CC(C)CC1=CC=C([C@@H](C)C(NS(C)(=O)=O)=O)C=C1
InChi Code
InChI=1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)/t11-/m1/s1
InChi Key
KQDRVXQXKZXMHP-LLVKDONJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-17350-1 |
|---|---|
| Supplier Part Number | 17350-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| ProductLine | CAYM |
| GroupName | Biochemical Compounds |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 266359-83-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |