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Cayman STF-083010
List Price $94.00 Your Price $94.00
Cayman STF-083010 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17370-10
MFG.PART: 17370-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
STF-083010 is an inhibitor of the IRE1/XBP1 pathway, blocking IRE1 endonuclease activity without affecting its kinase activity after endoplasmic reticulum (ER) stress both in vitro and in vivo. STF-083010 (60 µM) reduces the splicing of XBP1 by IRE1 in the presence of thapsigargin (Item No. ), an ER stress inducer. This has cytotoxic effects against multiple myeloma cells and drives apoptosis in pancreatic cancer cells.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[(2-hydroxy
CAS Number
307543-71-1
Synonyms
- IRE1 Inhibitor I
Molecular Formula
C15H11NO3S2
Formula Weight
317.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2 mg/mL
- DMF:PBS (pH 7.2) (1:7): 0.12 mg/mL
- DMSO: 1 mg/mL
λmax
224, 249, 338, 384 nm
SMILES
O=S(/N=C/C1=C2C(C=CC=C2)=CC=C1O)(C3=CC=CS3)=O
InChi Code
InChI=1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
InChi Key
TVIVJHZHPKNDAQ-MHWRWJLKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17370-10 |
|---|---|
| Supplier Part Number | 17370-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 307543-71-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |