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Cayman Gsk2636771; Purity- Greater Than Or Equal To 98%; Size- 1
List Price
$25.00
Your Price
$25.00
Cayman Gsk2636771; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17380-1
MFG.PART:
17380-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-3,4-bisphosphate (PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3). Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are four isoforms (p110α, p110β, p110δ, and p100γ), and a p85 regulatory subunit. GSK2636771 is an orally bioavailable inhibitor of PI3K p110β. At 1-10 µM, it decreases cell viability and Akt phosphorylation in p100β-dependent PTEN-deficient PC-3 prostate and BT549 and HCC70 breast cancer cell lines.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-methyl-1-
CAS Number
1372540-25-4
Molecular Formula
C22H22F3N3O3
Formula Weight
433.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
245, 345 nm
SMILES
OC(C1=CC(N2CCOCC2)=CC3=C1N=C(C)N3CC4=C(C)C(C(F)(F)F)=CC=C4)=O
InChi Code
InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
InChi Key
XTKLTGBKIDQGQL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17380-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 17380-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1372540-25-4 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |