We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman BI-2536
List Price
$834.00
Your Price
$834.00
Cayman BI-2536 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-17385-50
MFG.PART:
17385-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling.1 BI-2536 is a 2-aminopyrimidine-containing inhibitor of Plk1 (IC50 = 0.83 nM).2,3 It displays 4- and 11-fold selectivity for Plk1 over Plk2 and Plk3, respectively. BI-2536 induces mitotic arrest and apoptosis in diverse human cancer cell lines and drives regression of human tumor xenografts in nude mice.2 It shows good blood-brain barrier permeability and causes mitotic arrest in glioblastoma-derived neural stem cells but not normal neural stem cells.4 BI-2536 is also an inhibitor of BRD4 (IC50 = 25 nM), suppressing BRD4-dependent c-Myc expression in mm.1S multiple myeloma cells.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide
CAS Number
755038-02-9
Molecular Formula
C28H39N7O3
Formula Weight
521.7
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
λmax
210, 249, 345 nm
SMILES
O=C1[C@@H](CC)N(C2CCCC2)C3=NC(NC4=C(OC)C=C(C(NC5CCN(C)CC5)=O)C=C4)=NC=C3N1C
InChi Code
InChI=1S/C28H39N7O3/c1-5-22-27(37)34(3)23-17-29-28(32-25(23)35(22)20-8-6-7-9-20)31-21-11-10-18(16-24(21)38-4)26(36)30-19-12-14-33(2)15-13-19/h10-11,16-17,19-20,22H,5-9,12-15H2,1-4H3,(H,30,36)(H,29,31,32)/t22-/m1/s1
InChi Key
XQVVPGYIWAGRNI-JOCHJYFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-17385-50 |
|---|---|
| Supplier Part Number | 17385-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 755038-02-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |