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Cayman BQ-788 (sodium salt)
List Price $267.00 Your Price $267.00
Cayman BQ-788 (sodium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17403-1
MFG.PART: 17403-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
BQ-788 is a peptide endothelin type B (ETB) receptor antagonist (IC50 = 1.2 nM). It is selective for ETB over ETA receptors (IC50 = 280 nM), as well as angiotensin, calcitonin, or neuropeptide receptors at 10 µM. BQ-788 inhibits calcium mobilization induced by endothelin-1 (ET-1) in human Girrardi heart cells (IC50 = 0.54 nM) and vasoconstriction induced by the ETB-selective agonist BQ-3020 in isolated rat pulmonary arteries (PA2 = 8.4). In vivo, BQ-788 (1 mg/kg, i.v.) inhibits ET-1-induced depressor responses and induces pressor responses in rats. It protects against laparotomy and surgical gut handling-induced inhibition of intestinal motility in rats. BQ-788 also attenuates delayed hypotension, vascular hyporeactivity to norepinephrine, and hepatocellular injury and dysfunction in a rat model of LPS-induced endotoxemia.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine, monosodium salt
CAS Number
156161-89-6
Molecular Formula
C34H51N5O7 • Na
Formula Weight
664.8
Purity
≥95%
Formulation
A solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
229, 258, 286, 294 nm
SMILES
C[C@H]1N([C@H](CCC1)C)C(N[C@H](C(N[C@H](CC2=CN(C3=C2C=CC=C3)C(OC)=O)C(N[C@H](CCCC)C(O)=O)=O)=O)CC(C)(C)C)=O.[Na]
InChi Code
InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,4
InChi Key
IASLQTYUGYPLFB-FUKQNADPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-17403-1 |
|---|---|
| Supplier Part Number | 17403-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 156161-89-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |