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Cayman R-568
List Price $775.00 Your Price $775.00
Cayman R-568 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-17415-50
MFG.PART: 17415-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
R-568 is a calcimimetic and positive allosteric modulator of the calcium-sensing receptor (CaSR).1 It potentiates extracellular calcium-induced increases in intracellular calcium release and inhibits the secretion of parathyroid hormone (PTH; IC50 = 27 nM) in bovine parathyroid cells. R-568 decreases PTH and plasma calcium levels in rats (ED50s = 1.1 and 10.4 mg/kg, respectively).2 It suppresses parathyroid cell proliferation in a rat model of chronic renal insufficiency when administered at a dose of 15 mg/kg.3 Formulations containing R-568 have been used in the treatment of osteoporosis in post-menopausal women.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-chloro-N-[(1R)-
CAS Number
177172-49-5
Synonyms
- KRN 568
- NPS R-568
- Tecalcet
Molecular Formula
C18H22ClNO • HCl
Formula Weight
340.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 5 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 10 mg/mL
- PBS (pH 7.2): 5 mg/mL
λmax
213, 274 nm
SMILES
ClC1=C(CCCN[C@H](C)C2=CC=CC(OC)=C2)C=CC=C1.Cl
InChi Code
InChI=1S/C18H22ClNO.ClH/c1-14(16-8-5-10-17(13-16)21-2)20-12-6-9-15-7-3-4-11-18(15)19;/h3-5,7-8,10-11,13-14,20H,6,9,12H2,1-2H3;1H/t14-;/m1./s1
InChi Key
YJXUXANREVNZLH-PFEQFJNWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-17415-50 |
|---|---|
| Supplier Part Number | 17415-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 177172-49-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |