Cayman Bms 493; Purity- Greater Than Or Equal To 98%; Size- 1 Mg

Name: Cayman Bms 493; Purity- Greater Than Or Equal To 98%; Size- 1 Mg
SKU: CAYM-17418-1
Price: 44.00 USD

List Price $44.00 Your Price $44.00

Cayman Bms 493; Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-17418-1

MFG.PART: 17418-1

UNSPSC: 12352200

Manufacturer: Cayman

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Description

Product Description

Pituitary adenylate cyclase-activating peptide (PACAP) (1-27) is a PACAP receptor agonist with IC₅₀ values of 3, 2, and 5 nM, respectively, for rat PAC₁, rat VPAC₁, and human VPAC₂ recombinant receptors expressed in CHO cells. It binds to PACAP receptors in rat brain membrane (IC₅₀ = 9.55 nM) and to SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC₅₀s = 1.1, 1.9, and 0.9 nM, respectively).^, PACAP (1-27) stimulates cAMP accumulation in H-SY5Y, SK-N-MC, and T47D cells (EC₅₀s = 0.19, 0.22, and 0.17 nM, respectively). In vivo, in newborn pigs, PACAP (1-27) (1 μM) induces vasodilation of pial arterioles by 36%.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

L-histidyl-L-seryl-L-α-aspartylglycyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-tyrosyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-alanyl-L-alanyl-L-valyl-L-leucinamide, trifluoroacetate salt

Synonyms

Pituitary Adenylate Cyclase-activating Peptide (1-27)

Molecular Formula

C₁₄₂H₂₂₄N₄₀O₃₉S • XCF₃COOH

Formula Weight

3147.6

Purity

≥95%

Formulation

A lyophilized powder

Solubility

Water: 1 mg/ml

SMILES

NC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC(CNC([C@@H](NC([C@H](CO)NC([C@@H](N[H])CC1=CN=CN1)=O)=O)CC(O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)CC(O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)CCSC)=O)C)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)C)=O)C)=O)=O)=O.FC(F)(C(O)=O)F

InChi Code

InChI=1S/C142H224N40O39S.C2HF3O2/c1-16-75(10)113(179-108(191)66-156-120(201)102(63-109(192)193)173-135(216)104(67-183)176-119(200)88(146)62-84-65-153-70-157-84)139(220)174-101(58-80-28-18-17-19-29-80)133(214)182-114(79(14)186)140(221)175-103(64-110(194)195)132(213)178-106(69-185)136(217)172-100(61-83-39-45-87(189)46-40-83)131(212)177-105(68-184)134(215)164-93(34-27-54-155-142(151)152)126(207)170-98(59-81-35-41-85(187)42-36-81)129(210)163-92(33-26-53-154-141(149)150)124(205)161-89(30-20-23-50-143)122(203)165-94(47-48-107(147)190)127(208)166-95(49-55-222-15)121(202)159-78(13)118(199)180-111(73(6)7)137(218)167-91(32-22-25-52-145)123(204)162-90(31-21-24-51-144)125(206)171-99(60-82-37-43-86(188)44-38-82)130(211)169-97(57-72(4)5)128(209)160-76(11)116(197)158-77(12)117(198)181-112(74(8)9)138(219)168-96(115(148)196)56-71(2)3;3-2(4,5)1(6)7/h17-19,28-29,35-46,65,70-79,88-106,111-114,183-189H,16,20-27,30-34,47-64,66-69,143-146H2,1-15H3,(H2,147,190)(H2,148,196)(H,153,157)(H,156,201)(H,158,197)(H,159,202)(H,160,209)(H,161,205)(H,162,204)(H,163,210)(H,164,215)(H,165,203)(H,166,208)(H,167,218)(H,168,219)(H,169,211)(H,170,207)(H,171,206)(H,172,217)(H,173,216)(H,174,220)(H,175,221)(H,176,200)(H,177,212)(H,178,213)(H,179,191)(H,180,199)(H,181,198)(H,182,214)(H,192,193)(H,194,195)(H4,149,150,154)(H4,151,152,155);(H,6,7)/t75-,76-,77-,78-,79+,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,111-,112-,113-,114-;/m0./s1

InChi Key

LANRWJFRMLMIGH-AZXQFOANSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-17418-1
Featured	No
Supplier Part Number	17418-1
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	Click here
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	United States
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	2
Hazardous	N
CAS Number	215030-90-3
Energy Star	No
Green	No
ACT Ecolabel	No
Controlled	N

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NETA PART NO.	Quantity

Cayman Bms 493; Purity- Greater Than Or Equal To 98%; Size- 1 Mg

Product Description

Technical Information

Shipping & Storage Information

Product Title